Is Adam Rose Have Gaucher's Disease? Illness, What Is Gaucher Disease? Is He Fine Now?

Is Adam Rose Have Gaucher’s Disease? – Adam Rose is an American actor, writer, and content creator. He voiced Ryan Malloy on The Henry and June Show and the Season 4 episode “Going the Extra Mile!” of the Nickelodeon animated sketch comedy series KaBlam! He is also a rare disease patient. He adopts dance at an early age, excelling at tap, jazz, and ballet. Adam Rose’s big-screen debut came in the 1997 film Deconstructing Harry.

Adam Rose is also known for voicing Peanut Otter in the Disney animated musical television series PB&J Otter, which ran for 65 episodes over three seasons from 1998 to 2000. 

Is Adam Rose Have Gaucher’s Disease? Illness

Is Adam Rose Have Gaucher's Disease? Illness

On 21 July 2016, Adam Rose shared a video titled “I Have Gaucher’s Disease” on his youtube channel. You can watch this video below ⬇

 

What Is Gaucher Disease? 

According to Wikipedia, Gaucher Disease or Gaucher’s disease is a genetic disorder in which glucocerebroside (a sphingolipid, also known as glucosylceramide) accumulates in cells and certain organs. The disorder is characterized by bruising, fatigue, anemia, low blood platelet count, and enlargement of the liver and spleen, and is caused by a hereditary deficiency of the enzyme glucocerebrosidase (also known as glucosylceramidase), which acts on glucocerebroside.

When the enzyme is defective, glucocerebroside accumulates, particularly in white blood cells and especially in macrophages (mononuclear leukocytes, which are often a target for intracellular parasites). Glucocerebroside can collect in the spleen, liver, kidneys, lungs, brain, and bone marrow.

Manifestations may include enlarged spleen and liver, liver malfunction, skeletal disorders or bone lesions that may be painful, severe neurological complications, swelling of lymph nodes and (occasionally) adjacent joints, distended abdomen, a brownish tint to the skin, anemia, low blood platelet count, and yellow fatty deposits on the white of the eye (sclera).

Persons seriously affected may also be more susceptible to infection. Some forms of Gaucher’s disease may be treated with enzyme replacement therapy.

The disease is caused by a recessive mutation in the GBA gene located on chromosome 1 and affects both males and females.

About one in 100 people in the United States are carriers of the most common type of Gaucher disease. The carrier rate among Ashkenazi Jews is 8.9% while the birth incidence is one in 450.

Gaucher’s disease is the most common of the lysosomal storage diseases. It is a form of sphingolipidosis (a subgroup of lysosomal storage diseases), as it involves the dysfunctional metabolism of sphingolipids.

The disease is named after the French physician Philippe Gaucher, who originally described it in 1882.

Gaucher Disease’s Signs and symptoms

  • Painless hepatomegaly and splenomegaly: the size of the spleen can be 1500–3000 g, as opposed to the normal size of 50–200 g. Splenomegaly may decrease the affected individual’s capacity for eating by exerting pressure on the stomach. While painless, enlargement of the spleen increases the risk of splenic rupture.
  • Hypersplenism and pancytopenia, the rapid and premature destruction of blood cells, leads to anemia, neutropenia, leukopenia, and thrombocytopenia (with an increased risk of infection and bleeding).
  • Cirrhosis of the liver is rare.
  • Severe pain associated with joints and bones occurs, frequently presenting in hips and knees.
  • Neurological symptoms occur only in some types of Gaucher’s (see below):
  • Type I: impaired olfaction and cognition
  • Type II: serious convulsions, hypertonia, intellectual disability, and apnea
  • Type III: muscle twitches known as myoclonus, convulsions, dementia, and ocular muscle apraxia
  • Parkinson’s disease is recognized as being more common in Gaucher’s disease patients and their heterozygous carrier relatives.
  • Osteoporosis: 75% of patients develop visible bony abnormalities due to the accumulated glucosylceramide. A deformity of the distal femur in the shape of an Erlenmeyer flask is commonly described.
  • Yellowish-brown skin pigmentation

Is He Fine Now?

Is He Fine Now?

We are not sure about Adam Rose is fine now or not. He hasn’t shared anything related to his health with the media or on any social media. Whenever we find out anything related to this topic then we update this information.     

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